Description

Bis(o-Trimethylsilyl)Thymine is a high-purity, organosilicon-protected derivative of the nucleobase thymine, widely used as a critical synthetic intermediate in organic and medicinal chemistry. Its primary value lies in its role as a versatile building block for the synthesis of modified nucleosides, nucleotides, and oligonucleotides, where it facilitates specific chemical transformations under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and biotechnology sectors, particularly those developing novel antiviral agents, anticancer drugs, and molecular probes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used as a protected monomer in the solid-phase synthesis of modified DNA and RNA strands for research and therapeutic applications.
• Medicinal Chemistry Research: Enables the introduction of the thymine moiety into complex molecules during structure-activity relationship (SAR) studies.
• Agrochemical Development: Intermediate in creating novel nucleoside-based pesticides and plant growth regulators.
• Chemical Biology: Serves as a precursor for labeled nucleosides used as probes in biochemical assays and diagnostic tools.
• Process Chemistry: Employed in scalable routes for the production of active pharmaceutical ingredients (APIs) containing thymine derivatives.

Basic Information

Product Name	Bis(o-Trimethylsilyl)Thymine
CAS No.	7288-28-0
Molecular Formula	C13H26N2O2Si2
Molecular Weight	298.53 g/mol
Synonyms	1,3-Bis(trimethylsilyl)thymine; 5-Methyl-1,3-bis(trimethylsilyl)-2,4(1H,3H)-pyrimidinedione; Thymine, 1,3-bis(trimethylsilyl)-; N,O-Bis(trimethylsilyl)thymine; BTS-Thymine; Bistrimethylsilyl thymine
EINECS	Contact for details

Quality Control

Our Bis(o-Trimethylsilyl)Thymine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.