Description

Estropipate is a synthetic estrogen derivative, specifically the piperazine salt of estrone sulfate, widely recognized for its pharmaceutical applications. This compound is valued for its stability and bioavailability, making it a critical active pharmaceutical ingredient (API) in hormone replacement therapy (HRT) formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions developing treatments for menopausal symptoms and other estrogen-deficiency related conditions.

Application

• Pharmaceutical API: Primary use as the active ingredient in hormone replacement therapy (HRT) medications for managing menopausal symptoms such as hot flashes and vaginal atrophy.
• Clinical Research: Serves as a reference standard and key material in preclinical and clinical studies investigating estrogen-related therapies.
• Drug Formulation: Used in the development and production of various dosage forms, including oral tablets and topical preparations.
• Biochemical Research: Employed in laboratory studies to understand estrogen receptor interactions and metabolic pathways.

Basic Information

Product Name	Estropipate
CAS No.	7280-37-7
Molecular Formula	C25H35NO6S
Molecular Weight	477.62 g/mol
Synonyms	Estrone Piperazine Sulfate; Piperazine Estrone Sulfate; Ogen (Trade Name); Ortho-Est; Sulestrex Piperazine; Estrone Sulfate Piperazine Salt; 3-Sulfooxyestra-1,3,5(10)-trien-17-one piperazine salt; Estropipate USP
EINECS	Contact for details

Quality Control

Our Estropipate is manufactured and tested to meet high-purity standards suitable for pharmaceutical applications. Quality assurance includes rigorous analytical testing against relevant pharmacopeial monographs. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, identity, and impurity profiles to ensure compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; appropriate handling procedures should be followed to maintain stability and potency.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.