Description

1,3,4,6-Tetra-o-Acetyl-2-Deoxy-2-Fluoro-B-D-Glucose is a key fluorinated carbohydrate intermediate, specifically a fluorinated glucose derivative with acetyl protecting groups. This compound is critical for the synthesis of novel pharmaceuticals and diagnostic agents, particularly in the development of Positron Emission Tomography (PET) tracers and antiviral drugs. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in nucleoside chemistry and radiopharmaceutical production. The precise structure enables targeted modifications essential for advanced medical research.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of fluorinated nucleoside analogs with potential antiviral and anticancer activity.
• PET Tracer Precursor: Used in the radiochemical synthesis of Fluorine-18 (18F) labeled glucose analogs for diagnostic imaging in oncology and neurology.
• Glycobiology Research: Serves as a substrate or inhibitor in studies of glycosidase enzymes and carbohydrate-processing pathways.
• Probe Development: Employed in creating molecular probes to study biological processes involving carbohydrate recognition and metabolism.
• Fine Chemical Synthesis: Acts as a specialized chiral synthon for constructing complex molecules in medicinal chemistry campaigns.

Basic Information

Product Name	1,3,4,6-Tetra-o-Acetyl-2-Deoxy-2-Fluoro-B-D-Glucose
CAS No.	7226-42-8
Molecular Formula	C14H19FO9
Molecular Weight	350.29 g/mol
Synonyms	2-Deoxy-2-fluoro-1,3,4,6-tetra-O-acetyl-β-D-glucopyranose; 2-Fluoro-2-deoxy-1,3,4,6-tetra-O-acetyl-β-D-glucose; 1,3,4,6-Tetra-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranose; Tetraacetyl-2-fluoro-2-deoxy-β-D-glucose; 2-Fluoro-2-deoxy-D-glucose tetraacetate; β-D-Glucopyranose, 2-deoxy-2-fluoro-, 1,3,4,6-tetraacetate; FDG Tetraacetate Precursor
EINECS	Contact for details

Quality Control

Our 1,3,4,6-Tetra-o-Acetyl-2-Deoxy-2-Fluoro-B-D-Glucose is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical development. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC purity data, identity confirmation (NMR, IR), and impurity profiles. Production can adhere to cGMP guidelines for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]20/D	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.