Description

tert-Butyl Isocyanide is a versatile and highly reactive organic building block, essential for constructing complex molecular frameworks. Its primary value lies in its role as a key ligand in transition metal catalysis and a crucial component in multi-component reactions, enabling efficient synthesis in modern organic chemistry. This compound is critically needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of heterocyclic compounds and complex drug molecules, particularly in multi-component reactions like the Ugi and Passerini reactions.
• Catalysis & Ligand Chemistry: Serves as an isocyanide ligand for transition metals, facilitating various catalytic transformations in organic synthesis.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its reactivity to create new active structures.
• Material Science Research: Employed in the development of functional polymers, metal-organic frameworks (MOFs), and other advanced materials.
• Chemical Biology & Bioconjugation: Utilized as a bioorthogonal reagent for labeling and modifying biomolecules in probe development.
• Academic & Industrial R&D: A fundamental reagent for methodological development in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	tert-Butyl Isocyanide
CAS No.	7188-38-7
Molecular Formula	C5H9N
Molecular Weight	83.13 g/mol
Synonyms	2-Isocyano-2-methylpropane; (CH3)3CNC; tert-Butylisonitrile; t-Butyl Isocyanide; 2-Methyl-2-isocyanopropane; TBNC; NSC 9375
EINECS	Contact for details

Quality Control

Our tert-Butyl Isocyanide is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, NMR, and IR spectroscopy, to verify identity and assay. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and light-sensitive nature, store in a cool (15-25°C), well-ventilated place, away from heat and ignition sources. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.