Description

Levonorgestrel CAS NO 797-63-7 is a potent synthetic progestogen widely recognized for its critical role in hormonal pharmaceuticals. Its high biological activity and selectivity make it a cornerstone active pharmaceutical ingredient (API) for reproductive health solutions. This compound is essential for manufacturers in the global pharmaceutical industry developing contraceptive and hormone replacement therapies.

Application

• Pharmaceutical API: Primary active ingredient in oral contraceptive pills, including progestogen-only pills (POPs or "mini-pills").
• Emergency Contraception: Key component in dedicated emergency contraceptive pills (often combined with ethinyl estradiol).
• Hormone-Releasing Intrauterine Systems (IUDs/IUS): Used in long-acting reversible contraceptive devices that provide localized, sustained release.
• Subdermal Implants: Incorporated into biodegradable or non-biodegradable rods for long-term contraception.
• Hormone Replacement Therapy (HRT): Used in combination with estrogens for managing menopausal symptoms.
• Research & Development: Reference standard and key intermediate in pharmacological and endocrinological research.

Basic Information

Product Name	Levonorgestrel
CAS No.	797-63-7
Molecular Formula	C₂₁H₂₈O₂
Molecular Weight	312.45 g/mol
Synonyms	(-)-13β-Ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one; D(-)-Norgestrel; LNG; Levonorgestrelum; Wy-5104; 17α-Ethynyl-18-methyl-19-nortestosterone; (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
EINECS	212-344-1

Quality Control

Our Levonorgestrel is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards including USP, EP, and BP. Every batch undergoes comprehensive analytical testing including HPLC assay, related substances analysis, and residual solvent screening to ensure identity, purity, and safety. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer-specific validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Specific Rotation	-30° to -35° (c = 1 in chloroform)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.