Description

4-Nitrophenyl Chloroacetate is a specialized organic ester compound widely used as a key synthetic intermediate and biochemical reagent. This high-purity chemical is valued for its reactivity, particularly in the formation of ester bonds and as a substrate in enzymatic assays. It serves critical roles for research institutions and manufacturers in the pharmaceutical, agrochemical, and life science sectors. The compound is essential for synthesizing more complex molecules and studying reaction mechanisms.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs.
• Biochemical Research: Used as a chromogenic substrate for assaying the activity of esterase and lipase enzymes, where its hydrolysis releases 4-nitrophenol.
• Agrochemical Synthesis: Serves as a precursor in the manufacturing of certain herbicides and plant growth regulators.
• Polymer Chemistry: Acts as a monomer or modifying agent in the production of specialty polymers and functional materials.
• Organic Synthesis: Employed in peptide coupling reactions and as an acylating agent to introduce the chloroacetate group.
• Diagnostic Reagents: A component in the formulation of kits for clinical diagnostics and biochemical testing.

Basic Information

Product Name	4-Nitrophenyl Chloroacetate
CAS No.	777-84-4
Molecular Formula	C8H6ClNO4
Molecular Weight	215.59 g/mol
Synonyms	p-Nitrophenyl Chloroacetate; 4-Nitrophenyl 2-Chloroacetate; 2-Chloroacetic Acid 4-Nitrophenyl Ester; Chloroacetic Acid p-Nitrophenyl Ester; PNCA; 4-Nitrofenylchloracetát (Czech); NSC 401579
EINECS	212-307-6

Quality Control

Our 4-Nitrophenyl Chloroacetate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, melting point, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure the container is kept tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92°C - 96°C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.