Description

n-(Trifluoroacetyl)Glycine Butyl Ester is a specialized fluorinated glycine derivative, serving as a crucial protected amino acid building block. This compound is essential for the synthesis of complex peptides and peptidomimetics, where its trifluoroacetyl group provides orthogonal protection strategies. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of high-value active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: A key protected intermediate for the solid-phase and solution-phase synthesis of novel peptides.
• Medicinal Chemistry: Used in the research and development of new drug candidates, particularly in creating libraries of fluorinated analogs.
• Pharmaceutical Intermediates: Serves as a building block in the multi-step synthesis of complex target molecules for clinical trials and commercial production.
• Bioconjugation: Facilitates the site-specific modification of proteins and other biomolecules for diagnostic or therapeutic purposes.
• Agrochemical Research: Employed in the development of advanced fluorinated pesticides and herbicides, leveraging the properties of the trifluoromethyl group.
• Material Science: Acts as a monomer or precursor for specialty polymers and coatings with unique surface properties.

Basic Information

Product Name	n-(Trifluoroacetyl)Glycine Butyl Ester
CAS No.	764-16-9
Molecular Formula	C8H12F3NO3
Molecular Weight	227.18 g/mol
Synonyms	N-(Trifluoroacetyl)glycine butyl ester; Butyl 2-(trifluoroacetamido)acetate; 2-[(Trifluoroacetyl)amino]acetic Acid Butyl Ester; Glycine, N-(trifluoroacetyl)-, butyl ester; Butyl N-Trifluoroacetylglycinate; N-Trifluoroacetylglycine Butyl Ester; TFA-Gly-OBu
EINECS	212-124-5

Quality Control

Our n-(Trifluoroacetyl)Glycine Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, and custom synthesis to meet specific purity or packaging requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.