Description

n-Tfa-L-Proline Methyl Ester is a protected amino acid derivative, specifically the methyl ester of L-proline with a trifluoroacetyl (Tfa) protecting group on the nitrogen. This compound is a crucial chiral building block and intermediate in organic synthesis, valued for its role in facilitating complex peptide coupling and medicinal chemistry workflows. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptidomimetics, and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Serves as a protected proline residue in solid-phase and solution-phase peptide synthesis, enabling the construction of proline-containing peptides.
• Medicinal Chemistry & Drug Discovery: Used in structure-activity relationship (SAR) studies and the preparation of compound libraries for screening.
• Bioconjugation: Acts as a precursor for creating labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective organic reactions.
• Academic & Industrial R&D: A fundamental reagent for research in organic chemistry, biochemistry, and chemical biology.

Basic Information

Product Name	n-Tfa-L-Proline Methyl Ester
CAS No.	715-58-2
Molecular Formula	C8H10F3NO3
Molecular Weight	225.17 g/mol
Synonyms	L-Proline, N-[(trifluoroacetyl)]-, methyl ester; Methyl (2S)-1-(trifluoroacetyl)pyrrolidine-2-carboxylate; (S)-1-(Trifluoroacetyl)pyrrolidine-2-carboxylic acid methyl ester; N-Trifluoroacetyl-L-proline methyl ester; TFA-L-Pro-OMe; N-Tfa-L-Pro-OMe; N-α-Trifluoroacetyl-L-proline methyl ester; Methyl N-trifluoroacetyl-L-prolinate
EINECS	Contact for details

Quality Control

Our n-Tfa-L-Proline Methyl Ester is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Melting Point	Contact for details
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.