Description

Trimethyl Orthobenzoate is a specialized organic ester compound, serving as a versatile building block and protecting group in advanced organic synthesis. Its primary value lies in its ability to act as a precursor to benzoic acid derivatives and as a key reagent for introducing the orthoester functionality, which is crucial for controlled reactions in complex molecule construction. This high-purity intermediate is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries, where precise molecular assembly is required.

Application

• Pharmaceutical Intermediates: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly as a protecting group for carboxylic acids or as a precursor in heterocyclic chemistry.
• Agrochemical Synthesis: Serves as a key building block for creating herbicides, fungicides, and plant growth regulators that require specific benzoate ester structures.
• Fine Chemical & Fragrance Manufacturing: Employed in the production of complex esters and aromatic compounds used in flavors, fragrances, and specialty materials.
• Polymer & Resin Modifiers: Acts as a cross-linking agent or monomer in the production of specialty polymers with enhanced thermal or chemical resistance.
• Organic Synthesis Reagent: Functions as a valuable reagent in academic and industrial R&D labs for methodologies like the Johnson-Claisen rearrangement and other orthoester-based transformations.
• Chemical Research: Utilized as a standard or starting material in methodological development and catalysis studies.

Basic Information

Product Name	Trimethyl Orthobenzoate
CAS No.	707-07-3
Molecular Formula	C10H14O3
Molecular Weight	182.22 g/mol
Synonyms	Benzoic Acid Trimethyl Orthoester; Trimethoxy(phenyl)methane; Methyl Orthobenzoate; Orthobenzoic Acid Trimethyl Ester; Phenyl Orthoformate Trimethyl Ether; TMOB; Trimethyl Benzoate Orthoester; Trimethyl Phenyl Orthoformate
EINECS	211-902-8

Quality Control

Our Trimethyl Orthobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical B2B applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.485 - 1.495
Density (20°C)	1.060 - 1.080 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.