Description

Triparanol CAS NO 78-41-1 is a synthetic organic compound belonging to the class of cholesterol-lowering agents. It functions as a selective inhibitor of the enzyme 24-dehydrocholesterol reductase, which plays a critical role in the final step of cholesterol biosynthesis. This compound is primarily utilized in pharmaceutical research and development, serving as a key reference standard and a valuable tool compound for studying lipid metabolism, atherosclerosis, and related biochemical pathways.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments and the validation of testing methods in quality control laboratories.
• Biochemical Research: Employed as a potent tool compound to investigate the cholesterol biosynthesis pathway and its inhibition.
• Mechanistic Studies: Facilitates research into the role of desmosterol accumulation in cellular function and disease models.
• Academic Research: Supports studies in pharmacology, medicinal chemistry, and metabolic disorders within university and institutional settings.
• Drug Discovery & Development: Acts as a lead compound or a comparator in the development of novel therapeutic agents targeting lipid disorders.

Basic Information

Product Name	Triparanol
CAS No.	78-41-1
Molecular Formula	C27H32ClNO
Molecular Weight	421.99 g/mol
Synonyms	MER-29; 1-[4-[2-(Diethylamino)ethoxy]phenyl]-1-(4-chlorophenyl)-2-phenylethanol; 2-(4-Chlorophenyl)-1-[4-[2-(diethylamino)ethoxy]phenyl]-1-phenylethanol; Triparanolum; Desmosterol Reductase Inhibitor; NSC-17788
EINECS	201-114-8

Quality Control

Our Triparanol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.