Description

2,2,2-Trifluoroethanol CAS NO 75-89-8 is a versatile fluorinated alcohol characterized by its strong electron-withdrawing trifluoromethyl group, making it a powerful solvent and a valuable building block in organic synthesis. Its unique properties, including high polarity and stability, are critical for applications demanding precise chemical reactivity and material performance. This compound is essential for industries such as pharmaceuticals, agrochemicals, and specialty polymers, where it serves as a key intermediate and reaction medium.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing fluorine for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, pesticides, and fungicides, where the trifluoromethyl group improves efficacy and environmental profile.
• Specialty Polymer & Resin Modifier: Imparts desirable properties like chemical resistance, low surface energy, and thermal stability to coatings, adhesives, and high-performance plastics.
• Electronics & Semiconductor Processing: Employed as a precision cleaning solvent and etching agent in the manufacture of microelectronic components due to its high purity and volatility.
• Peptide Synthesis & Biochemistry: Acts as a solvent for protecting group removal and in various bioconjugation techniques.
• Laboratory Research & Organic Synthesis: A valuable reagent and solvent for nucleophilic substitution, esterification, and as a co-solvent to enhance reaction rates and yields.

Basic Information

Product Name	2,2,2-Trifluoroethanol
CAS No.	75-89-8
Molecular Formula	C2H3F3O
Molecular Weight	100.04 g/mol
Synonyms	2,2,2-Trifluoroethyl Alcohol; Trifluoroethanol; TFE; 2,2,2-Trifluoro-1-ethanol; 1,1,1-Trifluoro-2-ethanol; Trifluoroethyl Alcohol; α,α,α-Trifluoroethanol; Perfluoroethanol; NSC 71959
EINECS	200-913-6

Quality Control

Our 2,2,2-Trifluoroethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure it meets the highest standards for purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its hygroscopic and highly volatile nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) when not in use to prevent moisture absorption and evaporation. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.5%
Water Content (KF)	≤ 0.05%
Acidity (as TFA)	≤ 0.01%
Refractive Index (n20D)	1.290 - 1.295
Density (20°C)	1.383 - 1.393 g/mL
Boiling Point	73 - 75°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.