Description

Deferoxamine CAS NO 70-51-9 is a potent, highly specific iron-chelating agent belonging to the hydroxamic acid class. Its primary value lies in its ability to bind free ferric iron (Fe³⁺) with high affinity, forming a stable, water-soluble complex that can be excreted. This mechanism is critical for managing conditions of iron overload and acute iron poisoning. It is an essential pharmaceutical active ingredient for manufacturers in the pharmaceutical, biotechnology, and clinical diagnostics sectors.

Application

• Pharmaceutical Ingredient: Primary use as the active pharmaceutical ingredient (API) in injectable formulations for the treatment of acute iron intoxication and chronic iron overload due to transfusion-dependent anemias (e.g., thalassemia).
• Chelation Therapy: Used in clinical settings for chelation therapy to reduce toxic iron accumulation in tissues, preventing organ damage.
• Research & Diagnostic Reagent: Employed in biochemical and cell culture research to create iron-deficient conditions or to study iron metabolism pathways.
• Contrast Agent Adjuvant: Investigational use in conjunction with certain MRI contrast agents to mitigate potential side effects.
• Veterinary Medicine: Application in veterinary practice for treating iron overload in animals.
• Laboratory Standard: Serves as a reference standard in analytical laboratories for method development and quality control of related pharmaceutical products.

Basic Information

Product Name	Deferoxamine
CAS No.	70-51-9
Molecular Formula	C25H48N6O8
Molecular Weight	560.68 g/mol
Synonyms	Deferoxamine Mesylate (salt form); Desferrioxamine B; DFO; DFO-B; DFOA; Desferal® (brand name); N'-[5-[Acetyl(hydroxy)amino]pentyl]-N-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-4-oxobutanoyl]hydroxyamino]pentyl]-N-hydroxybutanediamide; Deferoxamine B
EINECS	200-734-5

Quality Control

Our Deferoxamine is manufactured and tested to meet stringent pharmacopeial standards, including USP and EP monographs where applicable. Every batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety. A detailed Certificate of Analysis (COA) is provided, documenting results for assay, related substances, residual solvents, heavy metals, and microbiological quality. Our quality system is designed to support regulatory submissions for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Complies with EP/USP for non-sterile substances
pH (1% solution)	4.0 - 6.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.