Description

2-(4-Iodophenoxy)-5-(Trifluoromethyl)Pyridine is a high-value, multi-functional chemical intermediate characterized by its distinct pyridine core substituted with both an iodophenoxy group and a trifluoromethyl moiety. This compound matters for its role as a critical building block in advanced synthesis, offering unique reactivity and physicochemical properties derived from its halogen and fluorine substituents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the development of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for targeted therapies.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, leveraging the biological activity of the pyridine and trifluoromethyl groups.
• Ligand & Catalyst Development: Serves as a precursor for designing specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as components for OLEDs or conductive polymers.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl structures.
• Fluorine Chemistry Studies: A valuable compound for investigating the influence of the trifluoromethyl group on metabolic stability and lipophilicity in drug design.

Basic Information

Product Name	2-(4-Iodophenoxy)-5-(Trifluoromethyl)Pyridine
CAS No.	694449-19-9
Molecular Formula	C12H7F3INO
Molecular Weight	365.09 g/mol
Synonyms	5-(Trifluoromethyl)-2-(4-iodophenoxy)pyridine; 2-(4-Iodophenoxy)-5-(trifluoromethyl)pyridine; 2-(p-Iodophenoxy)-5-(trifluoromethyl)pyridine; 694449-19-9; 5-Trifluoromethyl-2-(4-iodophenoxy)pyridine; Pyridine, 2-(4-iodophenoxy)-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-(4-Iodophenoxy)-5-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.