Description

Difluoro Atorvastatin is a key fluorinated intermediate in the synthesis of advanced pharmaceutical compounds, offering enhanced metabolic stability and bioavailability for next-generation active pharmaceutical ingredients (APIs). This high-purity building block is critical for research and development in medicinal chemistry, enabling precise structural modifications. It is primarily utilized by pharmaceutical R&D laboratories and API manufacturers focused on cardiovascular and metabolic disease therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the synthetic pathway for novel statin analogs and other bioactive molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of fluorination on drug potency and pharmacokinetics.
• API Development: Serves as a precursor in the development and scale-up of new Active Pharmaceutical Ingredients (APIs), particularly for cardiovascular therapies.
• Process Chemistry: Employed in route scouting and optimization for the efficient, large-scale production of fluorinated target compounds.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Difluoro Atorvastatin
CAS No.	693794-20-6
Molecular Formula	C33H35F2N3O5
Molecular Weight	591.65 g/mol
Synonyms	(3R,5R)-7-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic Acid; Atorvastatin Difluoro Impurity; Atorvastatin Difluoro Analog; 1H-Pyrrole-1-heptanoic Acid, 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-], (3R,5R)-; Difluorinated Atorvastatin Derivative
EINECS	Contact for details

Quality Control

Our Difluoro Atorvastatin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.