Description

tert-Butyl 4,5-Dihydro-3H-Spiro[Benzo[B][1,4]Oxazepine-2,4'-Piperidine]-1'-Carboxylate is a sophisticated spirocyclic organic building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for constructing complex molecular architectures, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D teams, agrochemical innovators, and specialty chemical manufacturers seeking to develop novel active ingredients. The unique spiro-fused benzoxazepine-piperidine scaffold offers a versatile platform for creating new chemical entities with potential therapeutic applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for neurological and psychiatric targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional degrader molecules.
• Agrochemical Synthesis: Intermediate for developing new crop protection agents with novel modes of action.
• Chemical Biology Probes: Building block for creating tool compounds to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 4,5-Dihydro-3H-Spiro[Benzo[B][1,4]Oxazepine-2,4'-Piperidine]-1'-Carboxylate
CAS No.	693789-34-3
Molecular Formula	C18H26N2O3
Molecular Weight	318.41 g/mol
Synonyms	1'-Boc-1,2,3,4-tetrahydrospiro[benzo[b][1,4]oxazepine-2,4'-piperidine]; tert-Butyl 1,2,3,4-tetrahydrospiro[benzo[b][1,4]oxazepine-2,4'-piperidine]-1'-carboxylate; 1,2,3,4-Tetrahydrospiro[benzo[b][1,4]oxazepine-2,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1'-Boc-1,2,3,4-tetrahydrospiro[benzo[b][1,4]oxazepine-2,4'-piperidine]; Spiro[benzo[b][1,4]oxazepine-2,4'-piperidine]-1'-carboxylic acid, 4,5-dihydro-3H-, 1,1-dimethylethyl ester; 693789-34-3; Boc-protected spirocyclic benzoxazepine piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4,5-Dihydro-3H-Spiro[Benzo[B][1,4]Oxazepine-2,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. For advanced applications, we offer material produced under controlled environments suitable for pharmaceutical R&D, with documentation traceability available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and should be handled with appropriate precautions for strong acids/organic solvents. Keep away from heat, sparks, and open flame. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.