Description

Estetrol 17-Acetate is a synthetic steroid derivative, specifically an acetate ester of the natural estrogen estetrol. This compound is a key pharmaceutical intermediate of significant interest for the development of novel hormone therapies. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of next-generation selective estrogen receptor modulators (SERMs) and other endocrine-targeting agents. Its controlled structure allows for precise pharmacological activity and metabolic profile tuning in advanced drug formulations.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the synthesis of advanced estrogenic compounds and hormone replacement therapies.
• Research & Development: Used in biochemical and pharmacological research to study estrogen receptor interactions and metabolic pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Drug Discovery: Employed in the discovery and development of new SERMs (Selective Estrogen Receptor Modulators) with targeted tissue effects.
• Contraceptive Development: Investigated as a potential component in the development of new oral contraceptives with improved safety profiles.
• Menopausal Therapy R&D: Used in formulating and testing new treatments for menopausal symptoms and osteoporosis prevention.

Basic Information

Product Name	Estetrol 17-Acetate
CAS No.	690996-23-7
Molecular Formula	C22H30O5
Molecular Weight	374.47 g/mol
Synonyms	E4 17-Acetate; 15α-Hydroxyestra-1,3,5(10)-triene-3,16α,17β-triol 17-Acetate; Estetrol 17-Monoacetate; 17β-Acetoxy-15α,16α-dihydroxyestra-1,3,5(10)-trien-3-ol; 3,15α,16α-Trihydroxy-17β-acetoxyestra-1,3,5(10)-triene
EINECS	Contact for details

Quality Control

Our Estetrol 17-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.