Description

tert-Butyl 6-Bromo-4-Oxo-3,4-Dihydro-1'H-Spiro[1,3-Benzoxazine-2,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and heterocyclic structure. This compound is of critical importance for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new molecular entities.
• API Synthesis: Serves as a critical precursor in multi-step synthetic routes for the production of potential active pharmaceutical ingredients.
• Chemical Biology Probes: Utilized in the development of specialized probes for studying biological pathways and target engagement.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development.
• Academic Research: Used in university and institutional labs for advanced organic synthesis and heterocyclic chemistry studies.

Basic Information

Product Name	tert-Butyl 6-Bromo-4-Oxo-3,4-Dihydro-1'H-Spiro[1,3-Benzoxazine-2,4'-Piperidine]-1'-Carboxylate
CAS No.	690632-05-4
Molecular Formula	C17H21BrN2O3
Molecular Weight	381.27 g/mol
Synonyms	1'-Boc-6-Bromo-4-oxo-3,4-dihydro-1'H-spiro[1,3-benzoxazine-2,4'-piperidine]; 6-Bromo-1'H-spiro[1,3-benzoxazine-2,4'-piperidine]-4(3H)-one, 1'-(1,1-dimethylethyl) ester; tert-Butyl 6-bromo-4-oxospiro[1,3-benzoxazine-2,4'-piperidine]-1'-carboxylate; 1,1-Dimethylethyl 6-bromo-4-oxo-3,4-dihydro-1'H-spiro[1,3-benzoxazine-2,4'-piperidine]-1'-carboxylate; Boc-6-Bromo-spiro-benzoxazine-piperidine; 690632-05-4; Spiro[1,3-benzoxazine-2,4'-piperidine] intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Bromo-4-Oxo-3,4-Dihydro-1'H-Spiro[1,3-Benzoxazine-2,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.