Description

(3S,5S,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid is a high-purity synthetic intermediate of significant importance in modern pharmaceutical research and development. This compound serves as a critical building block in the synthesis of complex therapeutic agents, particularly those targeting metabolic and cardiovascular pathways. It is primarily sought after by pharmaceutical manufacturers, advanced research institutions, and custom synthesis facilities engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) for metabolic disorder treatments.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Serves as a critical chiral building block in scale-up and process development for new chemical entities (NCEs).
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CRAMOs) for bespoke client projects.
• Biochemical Research: Investigated for its role in modulating specific enzymatic pathways in preclinical studies.

Basic Information

Item	Detail
Product Name	(3S,5S,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid
CAS No.	688735-41-3
Molecular Formula	C29H28FNO4
Molecular Weight	473.54 g/mol
Synonyms	7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid; Pitavastatin intermediate; NK-104 intermediate; (3S,5S)-Pitavastatin lactone open chain form; Livalo® synthetic intermediate; (E)-(3R,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxyhept-6-enoic acid
EINECS	Contact for details

Quality Control

Our (3S,5S,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical development and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.