Description

5-Bromo-2-Methoxy-4-Trifluoromethyl Pyridine is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical development. It is primarily sought after by research chemists and process development scientists in the agrochemical and pharmaceutical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in kinase inhibitor and CNS-active molecule libraries.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and other functional materials requiring halogenated pyridine cores.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	5-Bromo-2-Methoxy-4-Trifluoromethyl Pyridine
CAS No.	688047-09-8
Molecular Formula	C8H5BrF3NO
Molecular Weight	256.03 g/mol
Synonyms	5-Bromo-2-methoxy-4-(trifluoromethyl)pyridine; 4-Trifluoromethyl-5-bromo-2-methoxypyridine; 2-Methoxy-5-bromo-4-trifluoromethylpyridine; Pyridine, 5-bromo-2-methoxy-4-(trifluoromethyl)-; 688047-09-8; 5-Br-2-MeO-4-CF3-Pyridine
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Methoxy-4-Trifluoromethyl Pyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and IR is supplied with each shipment. Our quality commitment supports compliance with ISO 9001 and relevant ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.