Description

trans-1'-Oxo-Spiro[Cyclohexane-1,3'(1'H)-Furo[3,4-C]Pyridine]-4-Carboxylic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic and fused heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for central nervous system (CNS) and other specialty targets.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of proprietary drug candidates, especially those with spirocyclic architectures.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis to explore new biological activities.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of target APIs under Good Manufacturing Practice (GMP) guidelines.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in API manufacturing.
• Biochemical Tool Compound: Utilized in preclinical research to investigate specific biological pathways and target engagement.

Basic Information

Item	Details
Product Name	trans-1'-Oxo-Spiro[Cyclohexane-1,3'(1'H)-Furo[3,4-C]Pyridine]-4-Carboxylic Acid Hydrochloride
CAS No.	687640-97-7
Molecular Formula	C14H16ClNO4
Molecular Weight	297.73 g/mol
Synonyms	trans-1'-Oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxylic acid hydrochloride; 1'-Oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxylic acid hydrochloride (trans-); Spiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxylic acid, 1'-oxo-, hydrochloride, (3'R)- (rel-); CAS 687640-97-7
EINECS	Contact for details

Quality Control

Our production of trans-1'-Oxo-Spiro[Cyclohexane-1,3'(1'H)-Furo[3,4-C]Pyridine]-4-Carboxylic Acid Hydrochloride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.