Description

Melphalan n-Oxide is a chemically modified derivative of the alkylating agent Melphalan, characterized by the oxidation of its nitrogen mustard moiety. This structural modification is of significant interest in pharmaceutical research for its potential to alter metabolic pathways, bioavailability, and therapeutic profiles. It serves as a critical pharmaceutical intermediate and reference standard for researchers and developers in oncology drug discovery and advanced medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of novel chemotherapeutic agents and prodrugs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC/QA) of related pharmaceutical compounds.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of nitrogen mustard derivatives and their metabolites.
• Prodrug Development: Serves as a model compound for designing targeted cancer therapies with modified activation mechanisms.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and cancer biology.

Basic Information

Product Name	Melphalan n-Oxide
CAS No.	685847-78-3
Molecular Formula	C13H19Cl2N3O3
Molecular Weight	336.21 g/mol
Synonyms	L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-N-oxide; L-Melphalan N-Oxide; Phenylalanine mustard N-oxide; L-Sarcolysin N-Oxide; 4-[Bis(2-chloroethyl)amino]-L-phenylalanine N-oxide; (2S)-2-Amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid N-oxide
EINECS	Contact for details

Quality Control

Our Melphalan n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for research use. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melphalan (Parent Compound)	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.