Description

3-Chloro-2,6-Difluoro-Isonicotinic Acid is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in enabling the precise construction of complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs for enhanced bioactivity and molecular tuning.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoro and chloro substituents contribute to potency and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized organic materials and liquid crystals, where the isonicotinic acid core provides a versatile handle for further modification.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects requiring precise halogenation patterns on a pyridine scaffold.

Basic Information

Product Name	3-Chloro-2,6-Difluoro-Isonicotinic Acid
CAS No.	685517-75-3
Molecular Formula	C6H2ClF2NO2
Molecular Weight	193.54 g/mol
Synonyms	3-Chloro-2,6-difluoropyridine-4-carboxylic Acid; 2,6-Difluoro-3-chloroisonicotinic Acid; 4-Pyridinecarboxylic acid, 3-chloro-2,6-difluoro-; 3-Chloro-2,6-difluoro-4-pyridinecarboxylic acid; 685517-75-3; Isonicotinic acid, 3-chloro-2,6-difluoro-
EINECS	Contact for details

Quality Control

Our 3-Chloro-2,6-Difluoro-Isonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for advanced intermediate applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.