Description

1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridin-5-Ol is a high-value, organosilicon-protected pyrrolopyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in its role as a key building block for constructing complex heterocyclic scaffolds found in active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise, high-purity intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics targeting various disease pathways.
• Agrochemical Synthesis: Used in the research and development of advanced crop protection agents and pesticides, leveraging its unique heterocyclic structure.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as charge-transport layers or light-emitting components.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of complex target molecules in industrial settings.
• Academic & Contract Research: A valuable reagent for methodology development and exploratory synthesis in university and CRO laboratories.

Basic Information

Product Name	1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridin-5-Ol
CAS No.	685514-01-6
Molecular Formula	C17H28N2OSi
Molecular Weight	304.51 g/mol
Synonyms	5-Hydroxy-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-(triisopropylsilyl)-; TIPS-Pyrrolopyridin-5-ol; 1-TIPS-1H-pyrrolo[2,3-b]pyridin-5-ol; 5-Hydroxy-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; 685514-01-6; 1-(Triisopropylsilyl)-5-hydroxy-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridin-5-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.