Description

1H-Pyrrolo[2,3-B]Pyridin-5-Ol, 4-Chloro-1-[Tris(1-Methylethyl)Silyl]- is a high-value, organosilicon-protected pyrrolopyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary commercial value lies in enabling the efficient and selective construction of complex nitrogen-containing heterocycles, which are core scaffolds in modern pharmaceuticals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require high-purity, structurally sophisticated building blocks for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors, particularly those targeting oncology and inflammatory disease pathways.
• Agrochemical Research: Used in the development of novel herbicides and fungicides that leverage its heterocyclic core for biological activity.
• Material Science Precursor: Serves as a monomer or functional unit in the creation of organic electronic materials and advanced polymers.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular signaling.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and medicinal chemistry programs.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridin-5-Ol, 4-Chloro-1-[Tris(1-Methylethyl)Silyl]-
CAS No.	685513-98-8
Molecular Formula	C16H25ClN2OSi
Molecular Weight	324.92 g/mol
Synonyms	4-Chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol; 4-Chloro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridin-5-ol; 1-Triisopropylsilyl-4-chloro-1H-pyrrolo[2,3-b]pyridin-5-ol; 4-Chloro-5-hydroxy-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; TIPS-protected 4-chloropyrrolopyridinol; 685513-98-8; Pyrrolopyridine silyl ether derivative
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridin-5-Ol, 4-Chloro-1-[Tris(1-Methylethyl)Silyl]- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.