Description

1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 4-Chloro-1-[Tris(1-Methylethyl)Silyl]-, Methyl Ester is a high-value, organosilicon-protected heterocyclic building block critical for advanced organic synthesis. This compound matters because it provides a versatile and reactive scaffold for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of kinase inhibitors and other small-molecule therapeutics targeting various disease pathways.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Serves as a precursor for functionalized organic semiconductors and light-emitting materials in OLED research.
• Chemical Biology: Employed as a probe or linker in the design of chemical tools for studying biological systems and protein interactions.
• Process Chemistry: Utilized in route scouting and optimization for the scalable production of complex active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 4-Chloro-1-[Tris(1-Methylethyl)Silyl]-, Methyl Ester
CAS No.	685513-97-7
Molecular Formula	C18H27ClN2O2Si
Molecular Weight	366.96 g/mol
Synonyms	4-Chloro-1-[(triisopropylsilyl)]-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester; Methyl 4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate; 4-Chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester; 1-Triisopropylsilyl-4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester; TIPS-protected 4-chloro-7-azaindole-5-carboxylate
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 4-Chloro-1-[Tris(1-Methylethyl)Silyl]-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity suitable for sensitive R&D and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.