Description

4,5-Dichloro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, advanced pharmaceutical intermediate featuring a halogenated pyrrolopyridine core protected by a triisopropylsilyl (TIPS) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with potential biological activity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and biotechnology sectors.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly kinase inhibitors and other small-molecule therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new crop protection agents and herbicides.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Process Chemistry: Employed in route scouting and scale-up development for the efficient manufacturing of complex molecules.
• Material Science Research: Potential precursor for the synthesis of organic electronic materials and ligands for catalysis.

Basic Information

Product Name	4,5-Dichloro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	685513-95-5
Molecular Formula	C17H26Cl2N2Si
Molecular Weight	357.39 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 4,5-dichloro-1-[(1,1-dimethylethyl)dimethylsilyl]-; 4,5-Dichloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; TIPS-Protected 4,5-Dichloropyrrolopyridine; 4,5-Dichloro-1-(triisopropylsilyl)-7-azaindole; 685513-95-5; 4,5-Dichloro-1H-pyrrolo[2,3-b]pyridine, 1-(triisopropylsilyl)- derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, impurities, and other critical parameters are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.