Description

4-Chloro-5-Fluoro-1-[Tris(1-methylethyl)silyl]-1H-Pyrrolo[2,3-b]pyridine is a high-value, organosilicon-protected heterocyclic building block essential for advanced organic synthesis. This compound is specifically designed to facilitate complex molecular construction, offering a protected pyrrolopyridine core that is crucial for introducing structural complexity in target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other biological pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated heterocyclic structure.
• Material Science: Acts as a building block for creating organic semiconductors, ligands for catalysis, and other functional organic materials.
• Cross-Coupling Reactions: The silyl protecting group and halogen atoms make it a versatile substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Directed Functionalization: The protected nitrogen allows for regioselective further functionalization of the pyrrolopyridine scaffold.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and exploring new chemical space.

Basic Information

Product Name	4-Chloro-5-Fluoro-1-[Tris(1-methylethyl)silyl]-1H-Pyrrolo[2,3-b]pyridine
CAS No.	685513-94-4
Molecular Formula	C17H24ClFN2Si
Molecular Weight	338.92 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-fluoro-1-[tris(1-methylethyl)silyl]-; 4-Chloro-5-fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-5-fluoro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; 1-Triisopropylsilyl-4-chloro-5-fluoropyrrolo[2,3-b]pyridine; TIPS-4-Chloro-5-fluoropyrrolo[2,3-b]pyridine; CAS 685513-94-4
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Fluoro-1-[Tris(1-methylethyl)silyl]-1H-Pyrrolo[2,3-b]pyridine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.