Description

1H-Pyrrolo[2,3-B]Pyridin-5-Amine, 4-Fluoro-1-[Tris(1-Methylethyl)Silyl]- is a high-purity, protected heterocyclic amine building block of significant importance in advanced organic synthesis. This compound is specifically engineered to provide a reactive amine handle while offering enhanced stability and solubility through its silyl protecting group. It is a critical intermediate for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of novel kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex drug candidates, especially in oncology and antiviral research.
• Kinase Inhibitor Development: Serves as a core scaffold or substituent in the design and synthesis of potent and selective kinase inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides.
• Material Science Research: Employed in the creation of novel organic electronic materials and functional polymers.
• Chemical Biology Probes: Utilized to create labeled or tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring a fluorinated pyrrolopyridine backbone.

Basic Information

Item	Details
Product Name	1H-Pyrrolo[2,3-B]Pyridin-5-Amine, 4-Fluoro-1-[Tris(1-Methylethyl)Silyl]-
CAS No.	685513-93-3
Molecular Formula	C16H26FN3Si
Molecular Weight	307.48 g/mol
Synonyms	4-Fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-amine; 4-Fluoro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridin-5-amine; 1-Triisopropylsilyl-4-fluoro-1H-pyrrolo[2,3-b]pyridin-5-amine; 5-Amino-4-fluoro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; TIPS-Protected 4-Fluoro-5-aminopyrrolo[2,3-b]pyridine; 685513-93-3; 4-Fluoro-1H-pyrrolo[2,3-b]pyridin-5-amine, 1-(triisopropylsilyl)-
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridin-5-Amine, 4-Fluoro-1-[Tris(1-Methylethyl)Silyl]- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.