Description

1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-4-Fluoro-1-[Tris(1-Methylethyl)Silyl]- is a high-purity, advanced pharmaceutical intermediate featuring a halogenated pyrrolopyridine core protected by a bulky silyl group. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting kinase inhibitors and other biologically active small molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), particularly for kinase-targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the efficient production of candidate drugs.
• Bioconjugation & Probe Synthesis: The reactive halogen and protected nitrogen make it suitable for creating labeled compounds for biochemical assays.
• Academic Research: Serves as a specialized starting material in university and institutional labs for heterocyclic and organosilicon chemistry.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects requiring high-fidelity, functionalized heterocycles.

Basic Information

Item	Detail
Product Name	1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-4-Fluoro-1-[Tris(1-Methylethyl)Silyl]-
CAS No.	685513-91-1
Molecular Formula	C17H26BrFN2Si
Molecular Weight	385.39 g/mol
Synonyms	5-Bromo-4-fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-4-fluoro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; 1-Triisopropylsilyl-5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-4-fluoro-1-[tris(1-methylethyl)silyl]-; TIPS-5-Bromo-4-fluoro-7-azaindole; 5-Bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridine, 1-TIPS protected; 5-Br-4-F-1-TIPS-7-azaindole
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-4-Fluoro-1-[Tris(1-Methylethyl)Silyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request. We support development and commercial projects requiring material traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Handle and store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.