Description

5-Chloro-4-Fluoro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridin is a high-value, organosilicon-protected heterocyclic building block critical for advanced organic synthesis. Its primary value lies in serving as a key synthetic intermediate, enabling the precise construction of complex molecular architectures in a controlled manner. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in developing new pesticides and herbicides, leveraging its halogenated pyrrolopyridine core for bioactivity.
• Material Science: Serves as a building block for organic electronic materials, such as semiconductors and light-emitting compounds.
• Chemical Biology: Employed in the creation of molecular probes and labeled compounds for biochemical research.
• Cross-Coupling Reactions: The triisopropylsilyl (TIPS) group acts as a protective group, allowing for selective functionalization at other positions on the heterocycle.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Item	Details
Product Name	5-Chloro-4-Fluoro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridin
CAS No.	685513-90-0
Molecular Formula	C17H26ClFN2Si
Molecular Weight	340.94 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-chloro-4-fluoro-1-[(1,1-dimethylethyl)dimethylsilyl]-; 5-Chloro-4-fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1-TIPS-5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridine; 685513-90-0; TIPS-5-Chloro-4-fluoro-pyrrolo[2,3-b]pyridine; 5-Chloro-4-fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 5-Chloro-4-fluoro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-Fluoro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridin is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.