Description

1H-Pyrrolo[2,3-B]Pyridine, 4,5-Difluoro-1-[Tris(1-Methylethyl)Silyl]- is a high-value, organosilicon-protected heterocyclic building block of significant interest in advanced organic synthesis. This compound is specifically engineered to provide a reactive scaffold for the construction of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other biological pathways where the pyrrolopyridine core is pharmacologically active.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, leveraging its fluorinated heterocyclic structure for enhanced biological activity and environmental stability.
• Material Science Research: Acts as a building block for creating advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated system and silyl protection.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and tags for studying biological processes and protein functions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex, bespoke organic molecules for client projects.
• Academic Research: Utilized in university and institutional laboratories for methodological development in synthetic organic chemistry and the exploration of new chemical reactions involving protected nitrogen heterocycles.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4,5-Difluoro-1-[Tris(1-Methylethyl)Silyl]-
CAS No.	685513-89-7
Molecular Formula	C17H26F2N2Si
Molecular Weight	324.49 g/mol
Synonyms	4,5-Difluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1-Triisopropylsilyl-4,5-difluoropyrrolo[2,3-b]pyridine; 4,5-Difluoro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; TIPS-4,5-Difluoropyrrolo[2,3-b]pyridine; 1-[(Triisopropylsilyl)]-4,5-difluoro-1H-pyrrolo[2,3-b]pyridine; 4,5-Difluoro-1H-pyrrolo[2,3-b]pyridine, 1-[tris(1-methylethyl)silyl]-; 685513-89-7
EINECS	Contact for details

Quality Control

Every batch of 1H-Pyrrolo[2,3-B]Pyridine, 4,5-Difluoro-1-[Tris(1-Methylethyl)Silyl]- is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistent batch-to-batch quality suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.