Description

2-Hydroxy-4-(Trifluoromethyl)Nicotinic Acid is a high-value, fluorinated nicotinic acid derivative that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring both a hydroxyl group and a trifluoromethyl substituent on the pyridine ring, makes it an essential intermediate for creating compounds with enhanced biological activity and physicochemical properties. This product is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting enzymes and receptors.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can improve efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for advanced materials, such as organic semiconductors or metal-organic frameworks (MOFs).
• Chemical Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	2-Hydroxy-4-(Trifluoromethyl)Nicotinic Acid
CAS No.	685125-22-8
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	4-(Trifluoromethyl)-2-hydroxynicotinic acid; 2-Hydroxy-4-trifluoromethylnicotinic acid; 2-Hydroxy-4-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Carboxy-4-(trifluoromethyl)-2-pyridinol; 2-Pyridinol, 3-carboxy-4-(trifluoromethyl)-; 685125-22-8; Nicotinic acid, 2-hydroxy-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy-4-(Trifluoromethyl)Nicotinic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical-grade material is characterized by HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting purity, assay, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container must be kept tightly sealed due to the compound's sensitivity to light and potential moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.