Description

Ethyl 5-Cyano-6-Methyl-2-Homopiperazinonicotinate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is primarily required by R&D laboratories and manufacturing facilities in the global pharmaceutical and fine chemical industries for process development and scale-up.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of proprietary drug candidates, particularly in neurological and psychiatric research.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex piperazine and nicotinate-based molecular scaffolds.
• Preclinical Development: Serves as a critical material for producing batches of novel compounds for pharmacological screening and toxicology studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Chemical Reference Standard: High-purity material utilized for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	Ethyl 5-Cyano-6-Methyl-2-Homopiperazinonicotinate
CAS No.	683274-44-4
Molecular Formula	C15H20N4O2
Molecular Weight	288.35 g/mol
Synonyms	Ethyl 5-cyano-6-methyl-2-(homopiperazin-1-yl)nicotinate; 2-(1,4-Diazepan-1-yl)-5-cyano-6-methylnicotinic acid ethyl ester; 5-Cyano-6-methyl-2-(1,4-diazepan-1-yl)nicotinic acid ethyl ester; Ethyl 2-(1,4-diazepan-1-yl)-5-cyano-6-methylnicotinate; 683274-44-4; 2-(Homopiperazin-1-yl)-5-cyano-6-methylnicotinic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 5-Cyano-6-Methyl-2-Homopiperazinonicotinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the original container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.