Description

(R)-4,4'-Dibromo-1,1'-Spirobiindane-7,7'-Diol is a high-value chiral spirocyclic compound, serving as a critical building block in advanced organic synthesis. Its unique three-dimensional structure and bromine substituents make it an indispensable precursor for constructing complex, sterically demanding ligands and catalysts. This compound is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for applications in asymmetric catalysis and the development of novel active pharmaceutical ingredients (APIs).

Application

• Asymmetric Catalyst Synthesis: A key chiral scaffold for the development of novel phosphine, phosphoramidite, and N-heterocyclic carbene (NHC) ligands used in enantioselective transformations.
• Pharmaceutical Intermediate: Serves as a sophisticated precursor in the multi-step synthesis of complex drug candidates, particularly those requiring a rigid, chiral backbone.
• Material Science Research: Used in the development of chiral organic frameworks, polymers, and advanced materials with specific optical or electronic properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, exploring new C-C and C-X bond-forming reactions.

Basic Information

Product Name	(R)-4,4'-Dibromo-1,1'-Spirobiindane-7,7'-Diol
CAS No.	681481-94-7
Molecular Formula	C25H18Br2O2
Molecular Weight	518.22 g/mol
Synonyms	(R)-4,4'-Dibromospirobiindane-7,7'-diol; (R)-7,7'-Dihydroxy-4,4'-dibromo-1,1'-spirobiindane; (R)-Spirobiindane-7,7'-diol, 4,4'-dibromo-; (R)-4,4'-Dibromo-1,1'-spirobi[1H-indene]-7,7'(6H,6'H)-diol; (R)-Dibromospirobiindanediol
EINECS	Contact for details

Quality Control

Our (R)-4,4'-Dibromo-1,1'-Spirobiindane-7,7'-Diol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) verification by HPLC. A detailed Certificate of Analysis (COA) is supplied with each batch, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.