Description

1-Azaspiro[4.4]Non-7-Ene, 1-(Trifluoroacetyl)- (9Ci) is a specialized spirocyclic organic compound featuring a trifluoroacetyl-protected nitrogen, serving as a high-value synthetic intermediate. Its unique fused ring system and trifluoromethyl group make it a critical building block for constructing complex molecular architectures with enhanced metabolic stability and lipophilicity. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Research: Used in developing advanced herbicides and pesticides, where the spirocyclic and fluorine-containing motifs can improve biological activity and environmental persistence.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique thermal and chemical resistance properties.
• Ligand Synthesis: Employed in organometallic chemistry for creating novel chiral ligands used in asymmetric catalysis.
• Fluorine Chemistry Building Block: Provides a versatile scaffold for introducing the trifluoromethyl group into more complex molecules, a common strategy in modern medicinal chemistry.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies and exploring new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	1-Azaspiro[4.4]Non-7-Ene, 1-(Trifluoroacetyl)- (9Ci)
CAS No.	681283-60-3
Molecular Formula	C10H12F3NO
Molecular Weight	219.20 g/mol
Synonyms	1-(Trifluoroacetyl)-1-azaspiro[4.4]non-7-ene; 1-Azaspiro[4.4]non-7-ene, 1-(trifluoroacetyl)-; N-(Trifluoroacetyl)-1-azaspiro[4.4]non-7-ene; 1-Trifluoroacetyl-1-azaspiro[4.4]non-7-ene; 1-Azaspiro[4.4]non-7-ene, 1-(trifluoroacetyl)- (9CI); Spirocyclic Trifluoroacetamide Intermediate; 1-TFA-1-azaspiro[4.4]non-7-ene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide Certificates of Analysis (COA) with each batch, detailing purity and identity confirmation. Quality is assured through analytical techniques including HPLC, GC, NMR, and mass spectrometry. For custom synthesis projects, we adhere to cGMP guidelines as required, ensuring traceability and documentation for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.