Description

(2,6-Dichloro-5-Fluoropyridin-3-Yl)(Morpholino)Methanone is a high-purity fluorinated pyridine derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its value lies in its role as a sophisticated building block for synthesizing complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutics. This compound is essential for R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new fluorinated compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology treatments.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the fluoropyridine moiety can enhance biological activity and environmental stability.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry and process chemistry, enabling the exploration of new chemical spaces and structure-activity relationships (SAR).
• Ligand and Catalyst Precursor: Can be utilized in the preparation of specialized ligands for catalysis or as a precursor for metal-organic frameworks (MOFs) in material science applications.
• Fluorinated Compound Library Synthesis: Critical for combinatorial chemistry and high-throughput screening in drug discovery programs focused on fluorinated molecules.

Basic Information

Product Name	(2,6-Dichloro-5-Fluoropyridin-3-Yl)(Morpholino)Methanone
CAS No.	680217-88-3
Molecular Formula	C10H7Cl2FN2O2
Molecular Weight	277.08 g/mol
Synonyms	Morpholino(2,6-dichloro-5-fluoropyridin-3-yl)methanone; 2,6-Dichloro-5-fluoro-3-morpholin-4-ylcarbonylpyridine; 3-Morpholinocarbonyl-2,6-dichloro-5-fluoropyridine; 680217-88-3; (2,6-Dichloro-5-fluoro-3-pyridinyl)(4-morpholinyl)methanone; 5-Fluoro-2,6-dichloro-3-morpholin-4-ylcarbonylpyridine
EINECS	Contact for details

Quality Control

Our (2,6-Dichloro-5-Fluoropyridin-3-Yl)(Morpholino)Methanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up processes. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, purity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed and under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.