Description

2,6-Dichloro-5-Fluoro-n-Isopropylnicotinamide is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. Its core value lies in its role as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex fluorinated heterocycles. This compound is essential for research and manufacturing organizations in the pharmaceutical and agrochemical sectors seeking to develop next-generation products with enhanced efficacy and specificity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex fluorinated drug candidates, particularly in oncology and antiviral research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides, leveraging its halogenated nicotinamide structure.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemists exploring structure-activity relationships (SAR) in new molecular entities.
• API Manufacturing: Employed in regulated GMP processes for the production of active pharmaceutical ingredients requiring this specific fluorinated dichloro-substituted core.
• Custom Synthesis Building Block: Provided to fine chemical companies for use in multi-step custom synthesis projects for clients.

Basic Information

Product Name	2,6-Dichloro-5-Fluoro-n-Isopropylnicotinamide
CAS No.	680217-86-1
Molecular Formula	C9H9Cl2FN2O
Molecular Weight	263.09 g/mol
Synonyms	2,6-Dichloro-5-fluoro-N-(propan-2-yl)pyridine-3-carboxamide; 5-Fluoro-2,6-dichloro-N-isopropylnicotinamide; Nicotinamide, 2,6-dichloro-5-fluoro-N-(1-methylethyl)-; 680217-86-1; 2,6-Dichloro-5-fluoro-N-isopropyl-3-pyridinecarboxamide
EINECS	Contact for details

Quality Control

Our 2,6-Dichloro-5-Fluoro-n-Isopropylnicotinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.