Description

4-Chloro-2-(3-Fluorobenzyl)-6-Methyl-1H-Pyrrolo[3,4-C]Pyridine-1,3(2H)-Dione is a high-purity, advanced pharmaceutical intermediate with the CAS number 680216-24-4. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry. It is primarily sought by research organizations, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in scaling up synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final synthetic steps for producing target APIs with pyrrolopyridine core structures.
• Biochemical Research: Potential use as a tool compound or inhibitor in biochemical assays and proteomics research.
• Custom Synthesis: Basis for the custom manufacturing of specialized derivatives and analogs for client-specific research needs.

Basic Information

Product Name	4-Chloro-2-(3-Fluorobenzyl)-6-Methyl-1H-Pyrrolo[3,4-C]Pyridine-1,3(2H)-Dione
CAS No.	680216-24-4
Molecular Formula	C16H10ClFN2O2
Molecular Weight	316.71 g/mol
Synonyms	4-Chloro-2-[(3-fluorophenyl)methyl]-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione; 2-(3-Fluorobenzyl)-4-chloro-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione; 680216-24-4; 4-Chloro-2-(3-fluorobenzyl)-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3-dione; Pyrrolo[3,4-c]pyridine-1,3-dione, 4-chloro-2-[(3-fluorophenyl)methyl]-6-methyl-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot. We support development and commercial projects with material produced under quality agreements, ensuring traceability and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.