Description

3-(2,5-Dioxo-2,5-Dihydro-Pyrrol-1-Yl)-Benzoic Acid tert-Butyl Ester is a high-purity chemical intermediate featuring a maleimide-protected carboxylic acid group, enabling selective conjugation in complex synthetic pathways. This compound is critical for researchers and manufacturers requiring precise, stable, and efficient bioconjugation or polymer modification processes. It is primarily utilized in the development of advanced pharmaceuticals, sophisticated polymer materials, and specialized bioconjugates where controlled reactivity is paramount.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics via maleimide-thiol chemistry.
• Bioconjugation Reagent: Used for site-specific labeling of peptides, proteins, and antibodies with fluorophores, drugs, or other payloads.
• Polymer Science: Serves as a functional monomer or cross-linking agent in the production of specialty polymers, hydrogels, and smart materials.
• Proteomics Research: Employed in the design of activity-based probes and affinity tags for studying enzyme function and protein interactions.
• Material Surface Modification: Facilitates the covalent attachment of bioactive molecules to surfaces for biosensor and diagnostic device development.
• Chemical Biology Tool: Enables the study of cellular processes through the introduction of stable, cleavable, or detectable linkages into biomolecules.

Basic Information

Product Name	3-(2,5-Dioxo-2,5-Dihydro-Pyrrol-1-Yl)-Benzoic Acid tert-Butyl Ester
CAS No.	680185-88-0
Molecular Formula	C15H15NO4
Molecular Weight	273.28 g/mol
Synonyms	3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid tert-butyl ester; 1H-Pyrrole-1-benzoic acid, 2,5-dihydro-2,5-dioxo-3-(1,1-dimethylethyl) ester; tert-Butyl 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate; 3-Maleimidobenzoic Acid tert-Butyl Ester; Maleimido-Benzoic Acid t-Butyl Ester; MBTBE; t-Butyl 3-maleimidobenzoate
EINECS	Contact for details

Quality Control

Our 3-(2,5-Dioxo-2,5-Dihydro-Pyrrol-1-Yl)-Benzoic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.