Description

3-Pyridinecarboxylic Acid, 1,2,5,6-Tetrahydro-4-Hydroxy-, Methyl Ester (9Ci) is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research. It is primarily sought by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and biotechnology sectors for its precise stereochemistry and functional group compatibility.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates targeting neurological pathways.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry & Scale-Up: Serves as a standardized building block for optimizing synthetic routes from milligram to kilogram scale in API development.
• Biochemical Tool Compound: Potential use in biochemical assays as a modulator or probe for studying specific enzyme or receptor functions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.

Basic Information

Product Name	3-Pyridinecarboxylic Acid, 1,2,5,6-Tetrahydro-4-Hydroxy-, Methyl Ester (9Ci)
CAS No.	679841-12-4
Molecular Formula	C8H11NO3
Molecular Weight	169.18 g/mol
Synonyms	4-Hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylic acid methyl ester; Methyl 4-hydroxy-3,4,5,6-tetrahydro-2H-pyridine-3-carboxylate; 4-Hydroxy-1,2,5,6-tetrahydronicotinic acid methyl ester; 3-Carbomethoxy-4-hydroxy-1,2,5,6-tetrahydropyridine; Methyl 4-hydroxypiperidine-3-carboxylate (tautomer); 679841-12-4; Advanced nicotinate derivative
EINECS	Contact for details

Quality Control

Every batch of 3-Pyridinecarboxylic Acid, 1,2,5,6-Tetrahydro-4-Hydroxy-, Methyl Ester (9Ci) is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.