Description

tert-Butyl 7-Chloro-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its naphthyridine core structure. This compound is a critical building block in modern organic synthesis, valued for its role in constructing complex molecules with potential biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Organic Synthesis Building Block: Used in multi-step synthetic routes for constructing fused heterocyclic systems, leveraging its reactive chloro and carboxylate protecting groups.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Agrochemical Development: Potential application as an intermediate in the synthesis of novel herbicides or pesticides due to its heterocyclic scaffold.
• Academic & Industrial R&D: Utilized in chemical research laboratories for methodological development and exploring new catalytic or synthetic transformations.

Basic Information

Product Name	tert-Butyl 7-Chloro-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate
CAS No.	679392-23-5
Molecular Formula	C13H15ClN2O2
Molecular Weight	266.72 g/mol
Synonyms	1,8-Naphthyridine-1(2H)-carboxylic acid, 7-chloro-3,4-dihydro-, 1,1-dimethylethyl ester; 7-Chloro-1,2,3,4-tetrahydro-1,8-naphthyridine-1-carboxylic acid tert-butyl ester; tert-Butyl 7-chloro-1,2,3,4-tetrahydro-1,8-naphthyridine-1-carboxylate; 7-Chloro-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylic acid tert-butyl ester; BOC-7-Chloro-1,2,3,4-tetrahydro-1,8-naphthyridine
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 7-Chloro-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements or regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.