Description

5H-Inden-5-One, 1-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-1,2,3,6,7,7A-Hexahydro-4,7A-Dimethyl-, (1S,7As)- (9Ci) is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereospecific molecular structure. This compound is critical for enabling sophisticated synthetic pathways in modern organic chemistry, particularly in the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex, high-value therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug candidates, particularly in steroid-like or terpenoid-based therapeutic areas.
• Organic Synthesis Research: Used in academic and industrial R&D laboratories for developing new synthetic methodologies and exploring novel chemical spaces.
• Asymmetric Catalysis Studies: Serves as a sophisticated substrate or ligand precursor in the development and testing of new chiral catalysts.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for new chemical entities (NCEs).
• Reference Standard: Used as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	5H-Inden-5-One, 1-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-1,2,3,6,7,7A-Hexahydro-4,7A-Dimethyl-, (1S,7As)- (9Ci)
CAS No.	678159-99-4
Molecular Formula	C28H36O2Si
Molecular Weight	432.68 g/mol
Synonyms	(1S,7aS)-1-[(tert-Butyldiphenylsilyl)oxy]-1,2,3,6,7,7a-hexahydro-4,7a-dimethyl-5H-inden-5-one; tert-Butyldiphenylsilyl Ether of a Hexahydrodimethylindenone Derivative; (1S,7aS)-1-((tert-Butyldiphenylsilyl)oxy)-4,7a-dimethyloctahydroinden-5-one; TBDPS-protected Indanone Derivative; CAS 678159-99-4; Advanced Steroid Synthesis Intermediate; Chiral Silyl Ether Intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS to confirm identity, chiral purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to ensure traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.