Description

6-(Trifluoromethyl)-3-Pyridinethiol is a specialized organosulfur and heterocyclic building block featuring a reactive thiol group and a trifluoromethyl substituent on a pyridine core. This compound matters for its unique combination of electronic properties and reactivity, making it a valuable intermediate in advanced synthetic chemistry. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands in transition metal catalysis and organocatalysis due to the coordinating ability of the sulfur atom.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and conductive polymers, where its electronic properties can be tuned.
• Chemical Biology Probes: Utilized in the design of molecular probes and bioconjugation agents for studying protein function and cellular processes.
• Custom Synthesis and R&D: A critical reagent for contract research organizations (CROs) and academic laboratories engaged in novel heterocyclic chemistry and fluorine chemistry.

Basic Information

Product Name	6-(Trifluoromethyl)-3-Pyridinethiol
CAS No.	677772-36-0
Molecular Formula	C6H4F3NS
Molecular Weight	179.16 g/mol
Synonyms	3-Mercapto-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)pyridine-3-thiol; 3-Pyridinethiol, 6-(trifluoromethyl)-; 6-Trifluoromethyl-3-pyridinethiol; 3-Mercapto-6-trifluoromethylpyridine; 6-Trifluoromethylpyridine-3-thiol; 6-(Trifluoromethyl)-3-mercaptopyridine
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)-3-Pyridinethiol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.