Description

4-Amino-1-[3,5-o-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]-β-D-Ribofuranosyl]-1,3,5-Triazin-2(1H)-One is a sophisticated, high-purity nucleoside analog derivative, specifically designed for advanced pharmaceutical research and development. This compound is a critical protected intermediate used in the synthesis of novel antiviral and anticancer agents, where precise molecular architecture is paramount. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in cutting-edge nucleoside chemistry and oligonucleotide synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Oligonucleotide Synthesis: Used in the preparation of modified oligonucleotides for therapeutic applications, including antisense and siRNA technologies.
• Medicinal Chemistry Research: Serves as a protected precursor for structure-activity relationship (SAR) studies to optimize drug efficacy and pharmacokinetics.
• Process Chemistry Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) requiring protected ribofuranosyl triazine scaffolds.
• Bioconjugation: Potential use in creating targeted drug delivery systems by conjugating the amino group with specific ligands or carriers.

Basic Information

Product Name	4-Amino-1-[3,5-o-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]-β-D-Ribofuranosyl]-1,3,5-Triazin-2(1H)-One
CAS No.	676607-90-2
Molecular Formula	C21H40N4O6Si2
Molecular Weight	500.74 g/mol
Synonyms	4-Amino-1-(3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 1,3,5-Triazin-2(1H)-one, 4-amino-1-[3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-ribofuranosyl]-; TIPDS-protected 4-aminocytosine riboside derivative; 4-Amino-1-[(3,5-O-tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl]-1,3,5-triazin-2(1H)-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality control protocols, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical research. All materials are characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We operate under a cGMP-compliant quality management system to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions or a dry inert atmosphere to prevent decomposition. For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.