Description

tert-Butyl Spiro[Indole-3,4'-Piperidine]-1(2H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indole-piperidine scaffold. This compound is of critical importance for medicinal chemistry research and development, serving as a versatile and protected building block for the synthesis of novel bioactive molecules. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing central nervous system (CNS) agents, receptor modulators, and other therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key protected precursor in the multi-step synthesis of potential drug candidates, particularly those targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Spirocyclic Compound Synthesis: Essential for constructing complex spiro-fused heterocyclic systems, which are privileged structures in modern drug design due to their three-dimensionality and potential for high target selectivity.
• API Development: Employed in the research and process development stages for new active pharmaceutical ingredients (APIs), especially within the classes of sigma receptor ligands or 5-HT receptor modulators.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for clinical trials.
• Academic Research: Utilized in university and institutional labs for chemical biology studies and the development of new synthetic methodologies.

Basic Information

Product Name	tert-Butyl Spiro[Indole-3,4'-Piperidine]-1(2H)-Carboxylate
CAS No.	676607-31-1
Molecular Formula	C17H22N2O2
Molecular Weight	286.37 g/mol
Synonyms	1-Boc-spiro[indole-3,4'-piperidine]; tert-Butyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1-carboxylate; 1,2-Dihydrospiro[indole-3,4'-piperidine]-1-carboxylic acid 1,1-dimethylethyl ester; Spiro[indole-3,4'-piperidine]-1(2H)-carboxylic acid, 1,1-dimethylethyl ester; 1-N-Boc-spiro[indoline-3,4'-piperidine]; Boc-Spiro[Indoline-3,4'-Piperidine]; 676607-31-1
EINECS	Contact for details

Quality Control

Our tert-Butyl Spiro[Indole-3,4'-Piperidine]-1(2H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.