Description

3-Pyridinecarboxamide, n-(1,1-Dimethylethyl)-2-Methyl-6-(Trifluoromethyl)- is a specialized pyridine derivative characterized by its trifluoromethyl and tert-butyl amide substituents, offering unique steric and electronic properties. This compound is a high-value chemical intermediate critical for the synthesis of advanced molecules in regulated industries. It is primarily required by R&D and production teams in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and pesticides, leveraging the stability imparted by the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in organometallic chemistry and catalysis.
• Material Science Research: Employed in the development of novel organic electronic materials and functional polymers.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke chemical production.

Basic Information

Product Name	3-Pyridinecarboxamide, n-(1,1-Dimethylethyl)-2-Methyl-6-(Trifluoromethyl)-
CAS No.	676533-86-1
Molecular Formula	C12H15F3N2O
Molecular Weight	260.26 g/mol
Synonyms	N-tert-Butyl-2-methyl-6-(trifluoromethyl)nicotinamide; 2-Methyl-N-(tert-butyl)-6-(trifluoromethyl)pyridine-3-carboxamide; 6-(Trifluoromethyl)-2-methyl-N-(1,1-dimethylethyl)-3-pyridinecarboxamide; Nicotinamide, N-tert-butyl-2-methyl-6-(trifluoromethyl)-; 3-Carbamoyl-2-methyl-6-trifluoromethylpyridine, N-tert-butyl derivative; 676533-86-1; tert-Butyl 2-methyl-6-(trifluoromethyl)nicotinamide
EINECS	Contact for details

Quality Control

Our production of 3-Pyridinecarboxamide, n-(1,1-Dimethylethyl)-2-Methyl-6-(Trifluoromethyl)- adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment supports applications requiring GMP-grade intermediates and compliance with global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be sensitive to strong alkali and fluoride sources; store separately from such materials. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.