Description

6-(2,2,2-Trifluoroethoxy)Nicotinamide is a high-value fluorinated nicotinamide derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in the introduction of the trifluoroethoxy moiety, which can significantly alter the physicochemical and metabolic properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and insecticides where the trifluoroethoxy group enhances biological activity and environmental stability.
• Chemical Biology Probe: Serves as a versatile scaffold for creating molecular probes to study enzyme function and biological pathways, leveraging its fluorinated tag.
• Material Science: Potential monomer or additive in the development of specialty polymers and advanced materials with unique surface properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and process development projects on behalf of global clients.

Basic Information

Product Name	6-(2,2,2-Trifluoroethoxy)Nicotinamide
CAS No.	676533-51-0
Molecular Formula	C9H7F3N2O2
Molecular Weight	232.16 g/mol
Synonyms	6-(2,2,2-Trifluoroethoxy)pyridine-3-carboxamide; Nicotinamide, 6-(2,2,2-trifluoroethoxy)-; 3-Pyridinecarboxamide, 6-(2,2,2-trifluoroethoxy)-; 6-(Trifluoroethoxy)nicotinamide; 2,2,2-Trifluoroethyl 5-carbamoylpyridin-2-yl ether
EINECS	Contact for details

Quality Control

Our 6-(2,2,2-Trifluoroethoxy)Nicotinamide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.