Description

2-(2-Fluoro-Benzoyl)-3-Oxo-Butyric Acid Methyl Ester is a high-purity fluorinated β-keto ester building block, essential for advanced organic synthesis. This compound is valued for its precise molecular architecture, which enables the efficient construction of complex heterocyclic and pharmaceutical intermediates. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Heterocyclic Chemistry: Serves as a versatile scaffold for constructing complex heterocycles like pyrazoles, isoxazoles, and pyridines through condensation and cyclization reactions.
• Material Science Research: Employed in the development of advanced organic materials, including liquid crystals and organic semiconductors, due to its electron-withdrawing properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-(2-Fluoro-Benzoyl)-3-Oxo-Butyric Acid Methyl Ester
CAS No.	676348-59-7
Molecular Formula	C12H11FO4
Molecular Weight	238.21 g/mol
Synonyms	Methyl 2-(2-fluorobenzoyl)-3-oxobutanoate; Methyl 3-oxo-2-(2-fluorobenzoyl)butyrate; 2-(2-Fluorobenzoyl)-3-oxobutyric acid methyl ester; 3-Oxo-2-(2-fluorobenzoyl)butyric acid methyl ester; 2-Fluoro-α-(2-methoxy-2-oxoethylidene)benzenepropanoic acid methyl ester (tautomeric form); 2-(2-Fluorobenzoyl)acetoacetic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 2-(2-Fluoro-Benzoyl)-3-Oxo-Butyric Acid Methyl Ester adheres to stringent quality management protocols. Each batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and IR to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality system is designed to support cGMP requirements for pharmaceutical development and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.