Description

3-[3-(2-Chloro-Phenyl)-5-Methyl-Isoxazol-4-Yl]-3-Oxo-Propionic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific isoxazole and β-keto ester functional groups. This compound is of significant commercial importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Serves as a key scaffold for developing new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Chemical Research & Development: Used in academic and industrial R&D laboratories for exploring new chemical reactions and developing innovative synthetic methodologies.
• Fine Chemical Production: Employed in the manufacture of complex, high-value specialty chemicals for various industrial applications.
• Building Block for Heterocyclic Compounds: The isoxazole core is utilized to construct a wide array of other nitrogen- and oxygen-containing heterocycles of biological interest.

Basic Information

Product Name	3-[3-(2-Chloro-Phenyl)-5-Methyl-Isoxazol-4-Yl]-3-Oxo-Propionic Acid Methyl Ester
CAS No.	676348-52-0
Molecular Formula	C14H12ClNO4
Molecular Weight	293.70 g/mol
Synonyms	Methyl 3-[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]-3-oxopropanoate; 3-Oxo-3-[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]propionic Acid Methyl Ester; 2-Chloro-α-methyl-β-oxo-β-[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]propionic Acid Methyl Ester; Propanoic acid, 3-[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]-3-oxo-, methyl ester; Methyl 3-(3-(2-chlorophenyl)-5-methylisoxazol-4-yl)-3-oxopropanoate
EINECS	Contact for details

Quality Control

Our 3-[3-(2-Chloro-Phenyl)-5-Methyl-Isoxazol-4-Yl]-3-Oxo-Propionic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical development and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and hygroscopic; therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.