Description

tert-Butyl (4-(Chloromethyl)Pyridin-2-Yl)Carbamate is a high-purity, protected pyridine derivative serving as a critical building block in advanced organic synthesis. Its bifunctional structure, featuring both a carbamate-protected amine and a reactive chloromethyl group, makes it an indispensable intermediate for constructing complex molecules. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Used as a building block for creating advanced pesticides and herbicides with specific biological activity.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the creation of molecular probes and labeled compounds for biochemical research and diagnostic applications.
• Peptidomimetic Chemistry: Integral for introducing pyridine-based heterocycles into peptide backbones to enhance stability and bioavailability.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity intermediates.

Basic Information

Product Name	tert-Butyl (4-(Chloromethyl)Pyridin-2-Yl)Carbamate
CAS No.	672324-82-2
Molecular Formula	C11H15ClN2O2
Molecular Weight	242.70 g/mol
Synonyms	2-((tert-Butoxycarbonyl)amino)-4-(chloromethyl)pyridine; 4-(Chloromethyl)-2-pyridinylcarbamic Acid 1,1-Dimethylethyl Ester; tert-Butyl N-[4-(chloromethyl)pyridin-2-yl]carbamate; 2-(Boc-amino)-4-(chloromethyl)pyridine; Boc-4-Chloromethyl-2-aminopyridine; 4-(Chloromethyl)-2-((tert-butoxycarbonyl)amino)pyridine; N-Boc-2-Amino-4-chloromethylpyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl (4-(Chloromethyl)Pyridin-2-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. The container must be kept tightly sealed due to the compound's sensitivity to moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.